![]() ![]() Solubilized in the mixture and is different from said at least one Mixture, wherein said at least one second therapeutic agent is Preparation with at least one second therapeutic agent to form a ltoreq.0.1 (c) mixing the sized lipid vesicle particle ltoreq.120 nm and a polydispersity index (PDI) of Therapeutic agent, said sized lipid vesicle particles having a mean Vesicle particles and said at least one solubilized first Sized lipid vesicle particle preparation comprising sized lipid Vesicle particles and at least one solubilized first therapeuticĪgent (b) sizing the lipid vesicle particle preparation to form a Providing a lipid vesicle particle preparation comprising lipid Therapeutic agents, said method comprising the steps of: (a) A method for preparing a dried preparation comprising lipids and (Dartmouth, CA) SHARMA Arthvan (Halifax,ĬA) KALIAPERUMAL Valarmathy (Halifax, CA) WEIR Genevieve (Lawrencetown, CA) STANFORD Relating thereto, such as for example for inducing an antibody Hydrophobic carrier, as well as methods of treatment, uses and kits Single layer lipid assembly, at least two therapeutic agents, and a The presentĪpplication also provides stable, water-free pharmaceuticalĬompositions comprising one or more lipid-based structures having a ltoreq.120 nmĪnd a polydispersity index (PDI) of. Lipid vesicle particles to a mean particle size of. Therapeutic agents are incorporated both before and after sizing of Preparation comprising lipids and therapeutic agents whereby the The present disclosure relates to methods for preparing a dried ![]() SIZING OF LIPID VESICLE PARTICLES, AND USES THEREOF PHARMACEUTICAL COMPOSITIONS, METHODS FOR PREPARATION COMPRISING Invention is credited to Valarmathy KALIAPERUMAL, Andrea PENWELL, Rajkannan RAJAGOPALAN, Leeladhar SAMMATUR, Arthvan SHARMA, Marianne STANFORD, Genevieve WEIR. ![]() The applicant listed for this patent is IMMUNOVACCINE TECHNOLOGIES INC. This patent application is currently assigned to IMMUNOVACCINE TECHNOLOGIES INC. patent application number 16/762286 was filed with the patent office on for pharmaceutical compositions, methods for preparation comprising sizing of lipid vesicle particles, and uses thereof. ![]()
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I have had 4 kids – all of which were pretty good sleepers, and I wouldn’t say I saw any better or worse sleep because of the Dock a Tot. I will start this off with stating – I both LOVED the Dock a Tot, but also don’t think it is a need. Do You Really Need the Dock a Tot? An Honest Review from a Mom of 4Īlright So now you know what the Dock a Tot is – but lets talk about if you really need it. Then you can make an assessment on if you want/need the Grand down the road.ĭock a Tot Deluxe – The smaller ‘Baby’ Sizeĭock a Tot Grand – The larger ‘Toddler’ Size. You are only focusing on the Deluxe as that will get you through the first 8+ months of your babies life. If you are pregnant and registering for a baby don’t even think about the Grand yet. I have mentioned the Grand and the Deluxe already in this post, and some of you are probably thinking – what the heck? Those are names for different sizes. In my opinion – it is one of the earlier hard choices you have to make to decide what is right for you and your family. ** This is not recommended by the company or the American Academy of Pediatrics – it was simply a choice I made for my family. This is not recommended, but for me I found that doing so allowed for my anxiety of the baby being outside me to subside, while allowing each baby to have a dedicated place and not fully co sleep. I did lots of research on the safety, and felt very confident in the design and fabric choices that Dock a Tot made when designing their product, however still treaded lightly on infant use.įor us we used the Dock a tot as a portable napping space around the house, as well as a place for the baby to sleep for the first week or 2 in our bed. 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This leads her on a journey to Norway, having been told by her older sister that she remembers a man referred to only as ‘The Viking’ coming round when she was a baby. Newcastle-born David Leon ( Vera, RocknRolla) plays Charlie Henderson, Tasha’s mum’s boyfriend, who cruelly reveals to Tasha that he isn’t her real father. She said: “It is my first film and Reece has been doing it since he started to walk, so he was very protective and very helpful in my journey through it, he was lovely. She was 15 when she first auditioned for the role. Natasha Haws, from South Shields, plays heavily-pregnant Dasa opposite Reece Noi ( Game of Thrones, Grange Hill, Waterloo Road) as her baby’s father and Tasha’s brother, Danny. Little Mix star Jade Thirlwall, from South Shields, had auditioned for the role of Jenny before her pop career took off and a signed copy of the group’s debut single, Cannonball, features as a prop in the film. Tasha is played by Freya Parks ( Creation, Jane Eyre) and her elder sister, Jenny, is played by Lauren Johns ( Pride, Here and Now). Everyone gets on so well, it just put me at ease and Rita is such a great director.” “What made it so much better was having a good cast and crew. On the first day of filming I was very nervous, but once I got past the first couple of days I started enjoying it. “Working on my first feature film was obviously a very new experience, but it was all just a learning curve. ![]() She always follows her around and takes a lot of life lessons from her as well. She was cast after taking part in workshops at The Customs House when the film was in the early stages of development.Ĭhloe said: “Debbie is a very innocent and sweet character and she’s really loyal to her sister. ![]() It features a strong local cast, including Chloe Cuskin, from South Shields, who is making her film debut playing Tasha’s younger sister, Debbie. It’s really nice to be coming back to the north east for the premiere.”īliss! is a striking, modern-day rites-of-passage adventure about a 16-year-old girl, Tasha Robson, who sets out on an emotional journey to find her father. Osei, who will be travelling up from London for the premiere, said: “I am really excited. The opening night will feature a post-screening Q&A with the film’s director Rita Osei, Jarrow-born writer Alex Ferguson and local actress Natasha Haws. ![]() Home / News / SPECIAL SCREENING MARKS NORTH EAST FILM’S HOMECOMING SPECIAL SCREENING MARKS NORTH EAST FILM’S HOMECOMINGĪ film set in South Shields is coming home for its north east premiere.Ĭoming-of-age drama Bliss! will be shown for the first time in the region at The Customs House, in South Shields, on Friday, July 21, at 8pm. ![]() ![]() ![]() ![]() Microcrystalline varieties of quartz are subdivided based on the grain size, by the character of bands or opacity. Because of the different temperatures and pressure during the quartz formation, different impurities can get into the quartz structure.ĭifferent colors of quartz varieties are explained by impurities of various elements (Ti, Fe, Mg, Mn, Al) and inclusions of other minerals. ![]() The main reason is the different formation environments. And the separate occasion is oil inclusions.ĭepending on the habitus of quartz crystal, scepter quartz and Herkimer’s style quartz (double-terminated quartz crystals) can be distinguished.Īnd here we need to mention structural varieties of quartz ( polymorphs), which form under high-pressure, high-temperature conditions (from 20-80 kbar, from 800 up to 1750 oC). Other minerals can be found in quartz crystals: elbaite, actinolite, and chlorite. The most widespread is utilized quartz, where a gold-colored needle-like crystal of rutile (titanium oxide) is included in transparent quartz. Also, we will mention included quartz varieties here. They are aventurine quartz, and various ‘eyes’ (tiger’s eye, hawk’s eye, cat’s eye). Optical varieties of quartz are the next. The second group is microcrystalline varieties of quartz known as jasper, carnelian, chalcedony, onyx, agate, chert, and flint. The first group of quartz crystals is composed of well-known rock crystals, amethyst, citrine, ametrine, milky quartz, smoky quartz, and morion. Quartz varieties can be divided into two main groups and let’s say some phenomena. And even can from masses of rocks ( sandstone) composed of quartz grains only. It is highly resistant to weathering ( 7 on the Mohs scale) and tends to concentrate on sandstones and other detrital rocks. You can find it in acid igneous, metamorphic, and sedimentary rocks. Quartz occurs in nearly all types of rocks and geological environments. If you are interested in checking out the most beautiful quartz you can find them by clicking here (Amazon links) or here (). This variety of quartz forms two ended crystals and resembles the diamond’s outline. The Quartz family even has its own ‘diamond’, which name is the Herkimer diamond. Quartz is even found in meteorite craters and some varieties can be formed after a meteorite fall. Quartz can occur as beautiful crystals and cryptocrystalline aggregates, where no crystals can be observed, but colorful layers form intriguing patterns. Sometimes quartz forms such unusual forms that can be mistaken even with diamonds. Structural varieties are tridymite, cristobalite, coesite, and stishovite. Microcrystalline quartz varieties are jasper, carnelian, chalcedony, onyx, agate, chert, and flint. Quartz varieties are rock crystal, milk quartz, amethyst, citrine, ametrine, smoky quartz, morion, tiger’s eye, hawk’s eye, and aventurine. We will guide you through all the varieties of quartz known today. Quartz is accompanying humans for several thousand years and during this period it gathered numerous amount of names, which usually change from country to country. The chemical formula of quartz is quite simple SiO 2, but the range of colors, form of occurrences, and the presence of optical effects are multiple. Quartz is the mineral with the greatest amount of varieties. "Water plating" liquid is processed in an aqueous solution.As an Amazon Associate, I earn from qualifying purchases with no additional costs for you. Vacuum plating process complex, environment and equipment requirements, for the green environmental protection technology. ![]() Electroplating in the vacuum oven, and color retention time longer. Below is a brief comparison of ion plating, vacuum plating and water galvanization color durability. For the thickness of layer, it is influenced by the electroplating process and electroplating time, the longer the plating time, the thicker the plating layer is and the longer the color preserve. Difference between Ion Plating(IP) and Vacuum PlatingĮlectroplating process of our stainless steel jewelry is divided into three kinds, including vacuum ion plating(IP), vacuum plating and water electroplating. ![]() ![]() We’re excited to announce our latest entry to the storied Star Wars™ Pinball franchise, Star Wars™ Pinball: Rogue One™ is now available on PC and console and will come to mobile platforms on February 2nd. If the craft of each table matches the presentation in the platform, this should be a regular staple of any pinball-enjoying Switch owner.Star Wars™ Pinball: Rogue One™ – Now Available The future of this game will depend on how much Zen Studios supports it with new tables, but with 30 out there to start (with one free forever and two free for the first week), the diversity is there on day one. Pinball FX3 is an incredible platform for pinball tables, and while a lot of the focus is still on high score chasing, the variety of modes and options makes this deeper than the typical pinball game. (Editor’s Note: We will have some sort of round-up/review of the individual packs in the future.) I still had fun and eventually learned some of the tricks of the amusement park rides baked into this board. Adventure Land Pinball is fun as well, but the vibrant colors are too busy and it makes it very hard to spot specific elements of the board. I can see why Sorcerer’s Lair is the introductory table, because it does a good job of showing off some of the cool things Zen can do with pinball tables while looking more like a physical board. Sorcerer’s Lair has the clearest objectives that I’ve seen in a Zen table, but boy oh boy these kids shouting for their ghost buddy Whisper gets old fast. Telling the story of Hercules, this table is easy to comprehend, with a variety of challenges emerging as you battle snakes, Cerberus, and more. Of the three tables available for free right now, Son of Zeus is my favorite. Fortunately, touch screen controls are in here to make that less annoying, and are probably the best way to play the vertical mode. I just wish it didn’t feel like I was doing something illicit in the context of the game, as the controls in menus are as if you’re using two Joy-Con. HD rumble also adds a lot to this play style, making it feel more like an actual pinball table. The relative lack of clarity for the vertical mode makes me unsure if I can switch the buttons somehow, but as it stands, it works fine holding the system up vertically and pressing the left and right face buttons to flick the flippers. It’s easily toggled by the press of a button, but it’s not really clear that you can take off a Joy-Con and give your system a better feel for this mode. ![]() The Switch version’s big addition is a vertical mode in handheld. Having this kind of variety, and also rewarding players for exploring that variety, makes for a pinball experience that’s more than just slamming flippers and gunning for a singular high score. I actually find 5-Minute and Survival to be great introductions to tables, as 5-Minute just gives you five minutes with the board no matter what, while Survival requires you hit an incremental point threshold every minute to survive. Thanks to cross-system play with other platforms, the online experience is already well-populated with many tough contenders.Įach board also has three challenges: Single-Ball, 5-Minute, and Survival. Online multiplayer, either in the more head-to-head Matchup mode or broader Tournaments, is also present. Local hotseat multiplayer is an option here, too, which just offers a cleaner way to play with friends. ![]() ![]() Regular high scores can still be achieved, but it’s nice to have the option of progress through play in another way as well. As you play the board, upgrades are unlocked that boost your score on that table through percentage bonuses to multiball, bumper hits, and more. In addition to regular pinball play, various other options are available for every board. High scores for each and every mode are easily available, and as you play, the game tells you when you’re close to or pass a friend’s high score. Your profile accrues experience by playing pinball, leading to added customization and bragging rights. What makes Pinball FX3 so appealing is how everything is connected and varied. It’s a good spread, even if some of the licenses sound weird thanks to a bunch of questionable soundalikes. The other 27 tables out on day one range from original non-licensed works from Zen as well as licensed properties ranging from Back to the Future and E.T. At launch, Pinball FX3 features 30 tables, one of which is free (Sorcerer’s Lair) and two that are free from December 12 to 19 (Adventure Land Pinball and Son of Zeus). ![]() ![]() ![]() That’s great, but Kaspersky Password Manager doesn’t have the high-end features found elsewhere, like self-destructing messages or powerful sharing options. You also get leak detection and weak password checking. You can store documents in an encrypted vault, too. This app can store and autofill your payment details and addresses alongside login information, and synchronization across devices is near-instant. You can choose which special characters are allowed in a password, if any, but there’s no option to force it to create human-readable words.Įlsewhere, you get a conventional range of features. The password generator in Kaspersky Password Manager is a standard affair. The folder view is also a little bit harder to navigate than the simple list view that many other password managers use. You can create groups of entries, but there are no tags. In addition, we didn’t love the way that Kaspersky Password Manager organizes information. ![]() You’re able to create custom entries here, but you don’t get the templates, categories or level of control that you’l routinely find elsewhere. Kaspersky Password Manager has six, whereas competitors like mSecure have more than 20. The first is that there are fewer data categories. Kaspersky’s app interface will look familiar to anyone who has used another password manager, but there are some important differences. ![]() Kaspersky Password Manager: Interface and performance Helpfully, Kaspersky Password Manager supports importing entries from other popular password managers as well as CSV files. You can also download any stored credentials from your browsers to add them to your database. The first time you start the platform, it will prompt you to install a set of browser extensions to enable auto-filling. ![]() ![]() ![]() ![]() When Hunter returned to her hometown – Muskegon Heights, MI – she wanted to bring that Cajun taste with her, so she started creating her own spices. “Instead of having cake at birthday parties, people there would have a crab boil,” she says. Kaja Thornton Hunter discovered her love for Cajun cooking while living in Savannah, Georgia. “And part of a community that graciously supports us.”įinding Kaja’s Flavor in Muskegon Heights, MI “We love being part of the downtown,” Courtney says. They finally decided on a building owned by the Lakeshore Museum Center. We started to get that feel of community.” He introduced us to the restaurants and breweries. “He told us stories about the neighborhood and the history of the area. “We had somebody from the chamber spend a half-day walking us all over downtown looking at spaces,” Renee says. The result is Vintage Redefined, a home decor and lifestyle shop that opened in 2017 in downtown Muskegon. “One day we looked at each other and said, ‘Maybe we should do that.’ So we did,” Courtney says. Once they began taking items to craft shows, customers said they should open a shop. What started as a hobby turned into a business for Renee Doan and her daughter, Courtney Doan Leibrandt.įor years, they refinished vintage clothes and furniture for fun.
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